On the island of Gran Canaria, in the Vegueta neighborhood, close to the most significant structure of Canarian religious architecture, the Cathedral of the Canary Islands, the Plaza Mayor de Santa Ana is one of the city's most iconic locations. The General Patron Saint of the City of Las Palmas de Gran Canaria and the Titular of the Cathedral Basilica of the Canary Islands are honoured at the Plaza Mayor.

One of the earliest urbanizations of the Canary Islands was centred on the settlement of the Cathedral of the Canary Islands and the Plaza Mayor de Santa Ana. Around the Plaza de Santa Ana were constructed the City Hall, the Bishop's Palace, and the Cathedral. The Diocesan Museum of Sacred Art of Las Palmas de Gran Canaria is equally notable; it is located in the Patio de los Naranjos of the Cathedral of the Canary Islands. The Palacio Regental, the president of the Territorial Court's house, is located right next to the Plaza Mayor de Santa Ana.

The Columbus House Museum (Las Palmas de Gran Canaria), which honours Christopher Columbus' passage through and stay in the city of Las Palmas de Gran Canaria during his voyage to America, is located not far from the Plaza Mayor de Santa Ana, directly behind the Cathedral of the Canary Islands.

The sculpture group known as the Perros de la Plaza de Santa Ana is one of the square's symbols (Dogs of Santa Ana Square). It comprises of eight dog-themed sculptures that face the cathedral's front façade and are located at one end of the square. Even though they are painted green to look like bronze, they are actually composed of cast iron. Despite the fact that it is unknown exactly who made them, where they were made, or in which city, they were erected in the square in 1895. Over the years, the Santa Ana dogs have come to represent the city.