The historic district of Huelva, Spain, is known as the Casa Colón. Huelva is also the name of the region where these structures may be found. Formerly known as the "Hotel Colón," the structure has been repurposed as a conference centre and exhibition hall since its opening in 1883. It is classified as a "generic building" by the Junta de Andaluca and included in the General Catalogue of Andalusian Historical Heritage.

The Daz Hierro Municipal Archive and the Huelva Ibero-American Film Festival both call this building home.

Several mining businesses (including Rio Tinto Company Limited) and English and German merchants (like Guillermo Sundheim) relocated to the region of Huelva because of its abundance of valuable minerals. These industrialists had the bright idea of making the nation's capital one of the main ports for the country's massive mineral exports from the Cuenca Minera. They suggested building a hotel to house the notable visitors from abroad and host future events commemorating the 400th anniversary of the discovery of the Americas (for which it took the name of Admiral Christopher Columbus).

Between 1881 and 1883, the building cost six million reales to construct due to the need to create a hotel in Huelva to meet the need for services that the booming capital was expected to be requiring at the time. The architect José Pérez Santamara was hired by Sundheim to complete the project, and his design for the structure incorporated styles from the United Kingdom, Spain, and the Spanish colonies. A few years later, the Barrio Reina Victoria and the Hospital Inglés (both of which no longer exist) were constructed 500 metres apart, giving the city a decidedly English air.

The hotel, which opened in June 1883, quickly rose to prominence as one of Europe's finest resorts of its class. Their fresh and salt water baths, as well as rooms with private bathrooms, were provided by its own water supply system, at a period when the city itself had none. It was hailed as a fantastic spa in the contemporary press. In its original configuration, its four sections and central park occupied a two-hectare rectangular space.

There were two hundred rooms and lounges in the complex along with a restaurant, billiards room, ladies' lounge, reading room, smoking room, games room, and hair salon. One of its quirks was that every living area and bedroom had a fireplace and en suite bathroom. The hotel's dining room, which covered 380 square feet, was the suite's most impressive feature. Antonio Matarredona y Cuesta, a Renaissance artist, painted the elaborate murals that cover the ceilings of the rooms there.

Several notable people, including Charles Adams (who was named honorary president), J. Crofto, Hugo Lindemann, A. Lawson, G.M. Speirs, Gout, E. W. Palin, and the only two Spaniards, Pedro Soto and José Muoz, were present for the signing of the founding act of the Huelva Recreation Club on the 23rd of December 1889 in the chimney room. The newly formed Huelva Recreation Club is now the oldest club in Spanish football, having been the first to be founded in the country.

With the president of the government Cánovas del Castillo, ministers, representatives from Latin American countries, local authorities, etc., all gathering in Huelva for the commemorative acts of the IV Centenary of the Discovery of America in August 1892, our city was chosen as the venue for a tribute dinner. The Royal Family visited the city for the 12th of October festivity. Events were held in Huelva, Palos de la Frontera, and Moguer, and were visited by the regent Maria Cristina and her children King Alfonso XIII, the Princess of Asturias, Maria de las Mercedes, and the Infanta Maria Teresa. The Queen attended a number of ceremonies in the Plaza de la Merced before heading to the Hotel Colón for the formal closing session of the Congress of Americanists8 and a celebratory banquet in her honour.

It discontinued operations as a hotel after the IV Centenary of the Discovery of America, was renamed "Casa Colón," and is now used as an office and residence by the Rio Tinto Company Limited. Once the British left the mines, the building was owned by the Compaa Espaola de Minas de Ro Tinto and then the Explosivos Rio Tinto company before it was turned over to the city in 1986. During this time, the building's semi-derelict north pavilion was removed, erasing that section of the structure forever.

The original north building was renovated into a state-of-the-art conference centre by architects igo Manrique and Francisco Arqués in 1992 (to celebrate the 500th anniversary of the discovery of the Americas). Municipal architect for the City of Huelva, Francisco Javier Vallejo, was responsible for restoring all of the other preexisting structures. Inaugurated by King Juan Carlos I and Queen Sofa on August 3, 1992, a century after its original debut as the Hotel Colón, the renovated complex is now the cultural heart of the city.