Huesca is home to the parish church of Santo Domingo and San Martn. The parish church of San Martn de Tours was razed in the middle of the same century, and its congregation was relocated to the former Dominican temple, where they have worshipped ever since.

Don Alfonso, Prince of Aragon, established a Dominican monastery here in 1254. It was destroyed in 1362 along with other structures that were too close to the city wall at the behest of King Pedro IV of Aragon, who wanted to strengthen the city's defences against an impending Castilian invasion.

The monastery was torn down once more in 1687, this time to make way for a grander structure designed in the fashionable Baroque style. The rest of the Dominican community's structures have long since vanished, leaving behind only the church.

Fray Antonio Falcón completed construction on a new monastery in 1695. A magnificent dome, with well-made mural paintings in a clearly Baroque taste, in which the study of perspective stands out, crowns the transept, which has the same width as the three naves and was inspired by the churches built by the Jesuits. Tondos showing Mary's supplications from the litanies along the vault of the central nave.

A straight chancel characterises the presbytery. The walls and vaults are lavishly decorated in Baroque style with paintings, stucco reliefs, and tiled skirting boards. The Dominican coat of arms, the Inquisition's emblem, and a dog, an allusion to the Dominicans, are shown on the pulpit, in keeping with the Latin phrase "Domini canis" (dog of the Lord), which is phonetically identical to the word for Dominicans ("dominici"). So, just as the Lord's dog protects the flock by driving away predators, so too did the Dominican friars protect the faith by warding off heretics. The Dominicans' prominent role in the Inquisition's courts and, by extension, in the punishment of heresy, is widely recognised.

The tribunes over the side chapels are also made of the original wood and sit atop the preserved high choir at the foot of the main nave. In a trompe l'oeil style, windows are painted above them to appear partially open.

The front is made completely of brick and has a semicircular arched entryway, niche, and huge window in its central section, all of which lead up to a triangular pediment with an oculus. Concave walls connect two side streets that are narrower than the main roadway. Baroque in design and style, with a preponderance of squares and ovals in relief as ornamental elements. The Baroque ensemble is distorted by the later addition of a massive metal gateway that is linked to the façade. Since the parish church of Saint Martin was incorporated in 1868, the tower dates back to that year.

During the 19th century disentailment, the Dominican monastery was abandoned and its buildings were destroyed, with the exception of the church, which was repurposed as a parish church and later joined by the parish church of San Martn, which had been built to replace it.
All the important features—the transept and the main altarpiece—are located in the central nave.

Due to restoration work done in 1997, the church now provides a genuine representation of Counter-Reformation artwork.

It has a central nave with four bays vaulted with lunette arches that leads to a transept that is uniform in width and topped with a dome painted in outstanding Baroque style that culminates in a lantern. The apse is parallel to the nave and vaulted with a segment of lunette. There are eight total chapels, four on each side, built within the walls between the buttresses.