The church of San Cipriano is a Romanesque church dating back to the 11th century, although it was completely restored and refurbished at the end of the 20th century, giving it an eclectic appearance at the beginning of the 21st century. It is one of the oldest churches in the city. It was built with three naves, of which only one exists today, and of the two original façades, only the southern one remains. The church has a tower attached to its southwest corner. It has been a National Monument since 1931 and has been closed for worship. It is currently the venue for the concerts of the International Music Festival "Pórtico de Zamora".

The first news of its existence is recorded in the Regesta of Fernando II, published by Julio Gómez, when it is stated that the king was in Zamora in 1159. It also appears in a letter of donation from 1178. Some authors, such as Fernández Duro,5 date its existence back to 1022 based on the Roman numerals that appear on the chrism. Other authors even suggest its existence in 1025, during the reign of Alfonso V. In any case, it was a temple included in the walled enclosure.

It seems clear that there was a church there at the end of the 11th century, as shown by an inscription from 1093 and some reliefs of unknown origin, which have been embedded in different parts of the building. Later this building would be ruined and this one would be built, which has also undergone more than one substantial change in its organisation, as its primitive basilica plan has been reduced to a single nave, although with the triple straight chevet so typical of Zamora's Romanesque style. According to Ramos de Castro, the main chapel and the gospel chapel, the entrance to the epistle chapel and some parts of the north wall date from the end of the 11th century.

In the 12th century, the south wing was rebuilt and the tower was built over a passageway with a pointed arch, where sacred images were displayed for devotion. There was a well in the small atrium, which was covered by a dangerous well in the 1960s.

The church was rebuilt around 1980. In the 11th century it had three naves, each nave ending at the chancel with a small latticed window, with wrought ironwork of the period, some of the earliest surviving wrought ironwork in Spain.

In its beginnings it was a temple with three naves that has been lost over the centuries. The only remaining nave has a tripartite apse with a flat apse end. This apse is covered by barrel vaults. The three chapels are similar to those of Santo Tomé. The spaces dedicated to baptisteries and the sacristy were originally funerary chapels adjacent to the walls of the naves. Of the two entrances to the church that originally existed, only the one facing south has survived. This entrance consists of a semi-circular arch with three archivolts. The naves have a wooden roof that was installed in a 1975 refurbishment; this roof is supported by perpendicular arches.

Attached to the southwest corner of the building is a square tower with a sort of slate spire. The crown is pierced on each side by pairs of belfry openings. It dates from the mid-12th century. It is possible that it was a defensive watchtower on the old wall.