The Scuola Grande di San Rocco, located in Campo San Rocco, in the San Polo district of Venice, Italy, is an institution founded in 1478 by Venetians to provide aid during plague epidemics. San Rocco, whose relics are preserved in the nearby church that bears his name, was declared patron saint of the city in 1576. Annually, on his feast day on August 16, the Doge of Venice used to make a pilgrimage to the church.

This institution, known as a "scuola" in Venice, was a lay brotherhood that played a vital role in the social life of the city. The Scuola Grande di San Rocco had more than 500 members, and joined other important scuole such as St. Mark's and St. John the Evangelist.

The brotherhood acquired the mortal remains of St. Roch in 1485, which attracted numerous faithful and brought it benefits. From then on, it dedicated itself to assisting the victims of the plague. Construction of the church and the brotherhood house began in 1489 and continued until 1560, with several architects overseeing the work.

The interior decoration of the building was commissioned to Tintoretto, who created a remarkable series of paintings that marked a milestone in his career. Among other works of art, the Scuola features canvases by Titian, Giambattista Tiepolo and a 14th century Madonna and Child from the Byzantine school.

Tintoretto's most outstanding contribution was in the Sala dell'Albergo, where he painted a series of canvases on the life of Moses and scenes from the Old Testament on the ceiling. In the Sala Grande, he focused on New Testament themes and produced a series of works including The Last Supper and The Ascension. For the Lower Room, Tintoretto created eight canvases depicting scenes from the life of the Virgin and the infancy of Christ.

Tintoretto's work in the Scuola di San Rocco reflects his dramatic and theatrical style, with an intense narrative and rapid, vigorous execution. His contribution to the decoration of this place makes it one of the most outstanding examples of 16th century Venetian art.